PEPTiPEN RETA
Triple-Receptor GLP-1 · GIP · Glucagon Agonist
50 in stock
Retatrutide (LY-3437943) — triple-receptor peptide agonist structure
Molecular Science
Triple-Receptor Mechanism
Retatrutide is a novel triple-agonist peptide designed to simultaneously activate three metabolic receptors: GLP-1R (glucagon-like peptide-1 receptor), GIPR (glucose-dependent insulinotropic polypeptide receptor), and GcgR (glucagon receptor). This tri-receptor engagement is investigated for its unique capacity to modulate energy homeostasis, appetite signalling, and hepatic glucose output through complementary pathways.
Research Context
Research Applications
GLP-1R Agonism
Activates GLP-1 receptor pathways studied for appetite regulation and glucose-dependent insulin secretion in preclinical models.
GIP Receptor Activity
Dual GIP receptor engagement investigated for its role in metabolic rate modulation and adipose tissue biology.
Glucagon Agonism
Glucagon receptor activity studied for hepatic glucose output regulation and thermogenic pathway research.
Phase II Data
Published Phase II clinical trial data reported an average ~24% change in body weight parameters over 48 weeks in the trial population. Provided for scientific reference only.
Studied Research Areas
- GLP-1, GIP, and Glucagon receptor agonist — research compound
- Studied for appetite signalling pathways in preclinical models
- Investigated for metabolic rate pathways via glucagon receptor activity
- Examined for glucose and insulin sensitivity markers in research settings
- Preclinical research into body composition parameters
Active Compounds
Compound
Specification
Sterile, research-grade compounds supplied at documented concentrations for in vitro and preclinical research.
Retatrutide (LY-3437943)
Triple-receptor peptide agonist — active research compound
CAS 2381089-83-2Dosing Protocol
Metabolic Protocol
Dose increments for research calibration only. Not prescriptive for human or animal use.
Delivery System
Precision Auto-Injector Pen
Precision auto-injector research pen · 0.01 mg dose increments · Stainless steel mechanism · Replaceable cartridge
Research Use Only
For laboratory research use only by qualified personnel. Not for human or veterinary use. Not for use in food, drugs, cosmetics, or household applications. Handle only in accordance with the Safety Data Sheet and applicable workplace safety requirements.
